Psychosocial Resilience to Inflammation-Associated Depression: A Prospective Study of Breast-Cancer Survivors
研究乳腺癌女性患者中，心理社会资源（如社会支持、乐观等）能否缓冲压力对炎症相关抑郁症状的影响，发现资源丰富者压力与抑郁的关联更弱。
Stress can lead to depression, in part because of activation of inflammatory mechanisms. It is therefore critical to identify resilience factors that can buffer against these effects, but no research to date has evaluated whether psychosocial resilience mitigates the effects of stress on inflammation-associated depressive symptoms. We therefore examined psychosocial resources known to buffer against stress in a longitudinal study of women with breast cancer ( N = 187). Depressive symptoms and inflammation were measured over a 2-year period extending from after diagnosis into survivorship. Cancer-related stress and psychosocial resources—social support, optimism, positive affect, mastery, self-esteem, and mindfulness—were measured after diagnosis. As hypothesized, women who reported having more psychosocial resources showed weaker associations between stress and depressive symptoms and weaker associations between stress and inflammation-related depressive symptoms. Results highlight the importance of psychosocial resilience by demonstrating a relationship between psychosocial resources and sensitivity to inflammation-associated depressive symptoms.