Exact Decoding of a Sequentially Markov Coalescent Model in Genetics
提出一种新方法，在连续状态空间下对顺序马尔可夫溯祖模型进行精确推断，无需离散化，比现有方法更快更准，适用于基因型定相、重组率估计和种群历史推断。
In statistical genetics, the sequentially Markov coalescent (SMC) is an important family of models for approximating the distribution of genetic variation data under complex evolutionary models. Methods based on SMC are widely used in genetics and evolutionary biology, with significant applications to genotype phasing and imputation, recombination rate estimation, and inferring population history. SMC allows for likelihood-based inference using hidden Markov models (HMMs), where the latent variable represents a genealogy. Because genealogies are continuous, while HMMs are discrete, SMC requires discretizing the space of trees in a way that is awkward and creates bias. In this work, we propose a method that circumvents this requirement, enabling SMC-based inference to be performed in the natural setting of a continuous state space. We derive fast, exact procedures for frequentist and Bayesian inference using SMC. Compared to existing methods, ours requires minimal user intervention or parameter tuning, no numerical optimization or E-M, and is faster and more accurate.