Multivariate longitudinal analysis for the association between brain atrophy and cognitive impairment in prodromal Huntington’s disease subjects
提出一种测量误差校正方法，用于分析亨廷顿病前驱期患者脑萎缩与多种认知功能下降的纵向关联，帮助研究者理解疾病进展。
Cognitive impairment has been widely accepted as a disease progression measure prior to the onset of Huntington's disease. We propose a sophisticated measurement error correction method that can handle potentially correlated measurement errors in longitudinally collected exposures and multiple outcomes. The asymptotic theory for the proposed method is developed. A simulation study is conducted to demonstrate the satisfactory performance of the proposed two-stage fitting method and shows that the independent working correlation structure outperforms other alternatives. We conduct a comprehensive longitudinal analysis to assess how brain striatal atrophy affects impairment in various cognitive domains for Huntington's disease.