Controlling the false discovery rate in transformational sparsity: Split Knockoffs
提出一种名为分割敲除的数据自适应方法，用于在参数线性变换约束下的稀疏模型中控制错误发现率，通过变量与数据分割及新的逆超鞅结构实现可证明的FDR控制，模拟实验和阿尔茨海默病研究验证了其效果。
Abstract Controlling the False Discovery Rate (FDR) in a variable selection procedure is critical for reproducible discoveries, and it has been extensively studied in sparse linear models. However, it remains largely open in scenarios where the sparsity constraint is not directly imposed on the parameters but on a linear transformation of the parameters to be estimated. Examples of such scenarios include total variations, wavelet transforms, fused LASSO, and trend filtering. In this paper, we propose a data-adaptive FDR control method, called the Split Knockoff method, for this transformational sparsity setting. The proposed method exploits both variable and data splitting. The linear transformation constraint is relaxed to its Euclidean proximity in a lifted parameter space, which yields an orthogonal design that enables the orthogonal Split Knockoff construction. To overcome the challenge that exchangeability fails due to the heterogeneous noise brought by the transformation, new inverse supermartingale structures are developed via data splitting for provable FDR control without sacrificing power. Simulation experiments demonstrate that the proposed methodology achieves the desired FDR and power. We also provide an application to Alzheimer’s Disease study, where atrophy brain regions and their abnormal connections can be discovered based on a structural Magnetic Resonance Imaging dataset.