Funding of Clinical Trials and Reported Drug Efficacy
利用同一对药物在不同资助方试验中的比较，发现由制药商资助的试验报告其药物疗效显著更高，出版偏倚是重要原因，预注册可能有效克服此偏倚。
This paper estimates the effect of financial sponsorship of clinical trials on reported drug efficacy, leveraging the insight that the exact same pairs of drugs are often compared in different trials conducted by parties with different financial interests. I assemble new psychiatric trial data to estimate that a drug appears substantially more effective when the trial is sponsored by that drug’s manufacturer, compared with the same drug tested against the same combination of drugs but without sponsorship. This difference is not explained by observable characteristics, but publication bias is important. Preregistration may be effective in overcoming this bias.