Measuring lung diffusing capacity: an opportunity for improved medical surveillance and disability evaluation of coal miners
研究分析了3115名前煤矿工人的数据，发现20.2%存在肺弥散障碍，其中10%肺功能正常者也有此问题，表明弥散能力测试对早期发现肺部疾病有重要价值。
Objectives Spirometry is the primary lung function test utilised for medical surveillance and disability examination for coal mine dust lung disease. However, spirometry likely underestimates physiologic impairment. We sought to characterise abnormalities of single-breath diffusing capacity for carbon monoxide (D LCO ) among a population of former coal miners. Methods Data from 3115 former coal miners evaluated at a West Virginia black lung clinic between 2006 and 2015 were retrospectively analysed to study the association between diffusion impairment (abnormally low D LCO ), resting spirometry and the presence and severity of coal workers’ pneumoconiosis on chest radiography. We developed ordinary least squares linear regression models to evaluate factors associated with per cent predicted D LCO (D LCO pp). Results Diffusion impairment was identified in 20.2% of subjects. Ten per cent of all miners with normal spirometry had diffusion impairment including 7.4% of never smokers. The prevalence of diffusion impairment increased with worsening radiographic category of pneumoconiosis. Mean D LCO pp decreased with increasing small opacity profusion subcategory in miners without progressive massive fibrosis. Linear regression analysis also showed significant decreases in D LCO pp with increasing small opacity profusion and presence of large opacities. Conclusions Diffusion impairment is common among former coal miners, including among never smokers, miners without radiographic pneumoconiosis and miners with normal spirometry. These findings demonstrate the value of including D LCO testing in disability examinations of former coal miners and an important role for its use in medical surveillance of working miners to detect early chronic lung disease.