Building absolute breast cancer risk prediction models for women treated with chest radiation for Hodgkin lymphoma
基于霍奇金淋巴瘤幸存者队列，结合病例对照样本估计风险因素相对风险，并整合年龄特异性乳腺癌发病率和竞争死亡率，构建了绝对乳腺癌风险预测模型。
We built models to predict absolute breast cancer (BC) risk in women treated with radiotherapy for Hodgkin lymphoma (HL). We first estimated relative risks (RRs) for risk factors, including radiation dose to 10 breast segments to accommodate heterogeneity of treatment effects, using a case-control sample nested in an HL survivor cohort. To estimate RRs of case-control matching factors we developed novel weighting approaches. We then combined RRs with age-specific BC incidence and competing mortality rates from the HL survivor cohort and a population-based registry, accommodating differences between them. We compared the performance of models using segment-specific doses with using mean dose only.