Rotating shift work, with night shift work, affects cardiovascular risk factors: a 6-year follow-up study in the insulation industry
研究了绝缘行业含夜班的轮班工人与日班工人6年间心血管风险因素的变化，发现轮班工作与体重增加、炎症、动脉硬化等风险因素相关，减少夜班次数可缓解部分风险。
Objectives To assess absolute levels and longitudinal changes in cardiovascular disease (CVD) risk factors over 6 years among rotating shift workers with night shift work and day workers in industry. Methods We studied three groups, 32 night shift workers in Plant A with a high night load, 23 in Plant B with a low night load and 25 day workers during a 6-year follow-up (FU). We collected demographics by questionnaire, measured blood pressure, resting heart rate, carotid intima–media thickness (cIMT), carotid to femoral pulse wave velocity (cfPWV) and maximal oxygen uptake (V̇O 2max ). We analysed blood samples including lipids, glycosylated haemoglobin (HbA1c) and C reactive protein (CRP). Mixed models were used to assess changes and differences in changes of these outcomes between shift and day workers. Results Over the 6-year FU weight, cfPWV and CRP increased among shift workers with a high night load, and cIMT increased among shift workers with a low night load and among day workers. Over the 6-year FU, a significant decrease in V̇O 2max and an increase in HbA1c were found among all workers. The decrease in V̇O 2max and increase in HbA1c were associated with number of years in shift work. Conclusions Rotating shift work with night shift work in industry associates with weight increase, inflammation, arterial stiffness, increase in cIMT and HbA1c but also decreased V̇O 2max . Reducing the number of night shifts and including periods of restitution in the shift plan seem to mitigate some of the CVD risk factors.