Health Watch: cancer and mortality update in a 40-year prospective cohort study of Australian petroleum workers
该研究更新了澳大利亚石油工人队列40年随访的癌症发病率和死亡率数据，发现全因死亡率低于全国水平，但间皮瘤、黑色素瘤和前列腺癌风险持续偏高，提示需加强职业防护和监测。
OBJECTIVES: To report estimates of cancer incidence (1982-2016) and mortality (1980-2020) in the Health Watch cohort after four decades of follow-up. METHODS: Health Watch is a prospective cohort study of 18 040 (16 666 men, 1374 women) employees recruited between 1981 and 2000.Personal data were linked to national and state cancer and death registries. Standardised mortality ratios (SMRs) and standardised incidence ratios were calculated using national population rates adjusted for age, sex and calendar period. RESULTS: All-cause mortality was reduced compared with Australian population rates (men: SMR 0.79, 95% CI 0.77 to 0.82; women: SMR 0.70, 95% CI 0.59 to 0.83). CONCLUSIONS: Lower mortality likely reflects the healthy worker effect. Persistent excesses of mesothelioma, melanoma and prostate cancer may reflect ongoing occupational risks warranting targeted prevention and surveillance. In particular, melanoma risk underscores the need to minimise both occupational and recreational ultraviolet exposure.